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Dihydropteroate Synthetase (Plasmodium falciparum) (DHPS)

Target: DHPS
Molecular classification: Enzyme

Overview

Dihydropteroate synthetase (DHPS) is a key enzyme in the folate biosynthesis pathway of Plasmodium falciparum. DHPS catalyzes the condensation of para-aminobenzoic acid (pABA) with dihydropterin pyrophosphate to produce dihydropteroate. It is the target of sulfone and sulfonamide drugs like sulfadoxine, used in combination therapies to treat malaria. Resistance arises through point mutations in the dhps gene, particularly A437G, which reduce drug affinity.

Mechanism of action

Competitive inhibition of DHPS

Biological functions

Folate biosynthesisDNA synthesisCell division

Disease associations

Infection

Safety considerations

Drug resistance development due to mutations in the dhps gene

Interacting drugs

Sulfadoxine

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