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Target intelligence / Profile preview
Dihydropyrimidine dehydrogenase [NADP(+)] (DPD)
- Target
- DPD
- Molecular classification
- Enzyme, Oxidoreductase
01
Overview
Dihydropyrimidine dehydrogenase [NADP(+)] (DPD) is an enzyme that catalyzes the initial and rate-limiting step in the catabolism of pyrimidines, specifically uracil and thymine. It is crucial for breaking down these nucleotides. DPD also plays a major role in the metabolism of chemotherapeutic drugs like 5-fluorouracil (5-FU). Deficiency or genetic variants in DPYD can lead to severe toxicity upon administration of fluoropyrimidine drugs due to impaired drug breakdown.
- Other names
- Dihydrothymine dehydrogenaseDihydrouracil dehydrogenase (NADP+)DPYD_HUMANMGC132008MGC70799
02
Mechanism of action
Catalyzes the reduction of uracil to dihydrouracil and thymine to dihydrothymine, initiating their degradation. Metabolizes fluoropyrimidine drugs.
03
Biological functions
Pyrimidine catabolismReduction of uracilReduction of thymineDrug metabolism
04
Disease associations
Dihydropyrimidine dehydrogenase deficiencyDrug toxicity
05
Safety considerations
Severe toxicity with fluoropyrimidine chemotherapy (e.g., 5-FU)Dihydropyrimidine dehydrogenase deficiency
06
Interacting drugs
5-Fluorouracil (5-FU)
1 more in the full profile.
07
Biomarkers
DPYD gene variants (e.g., M166V, E828K, K861R, P1023T, D949V)
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