Target intelligence / Profile preview

Diphtheria Toxin (as carrier protein); commonly used form: CRM197 (None)

Target: None
Molecular classification: Exotoxin, Carrier Protein

Overview

Diphtheria toxin's genetically detoxified mutant CRM197 serves as an effective and safe carrier protein in many licensed conjugate vaccines due to its strong immunogenicity, lack of toxicity, structural stability, and suitability for chemical coupling with diverse antigens.

Other names: CRM197Diphtheria Toxin MutantNon-toxic Diphtheria Toxin

Mechanism of action

Conjugation to weak antigens enhances immune response and antibody production against the antigen.

Biological functions

Antigen deliveryImmunogenicity enhancement

Disease associations

Vaccine developmentInfection prevention (indirectly, via vaccine)

Safety considerations

Potential for carrier-induced suppressionRare allergic reactions to vaccine components

Interacting drugs

Pneumococcal conjugate vaccines (e.g., Prevnar®)

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