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Diphtheria toxin (as toxoid)

Molecular classification: Exotoxin, Toxoid

Overview

Diphtheria toxin is a potent exotoxin secreted primarily by Corynebacterium diphtheriae. The toxoid is an inactivated form of the toxin, produced by treating the purified diphtheria toxin with formaldehyde, retaining immunogenicity but losing toxicity, making it suitable for use in vaccines to induce protective immunity.

Other names: Diphtheria toxoidCorynebacterium diphtheriae toxinDiphtheria exotoxin

Mechanism of action

Induces IgG antitoxin antibodies that neutralize circulating toxins.

Biological functions

Inhibition of eukaryotic protein synthesisADP-ribosylation of EF-2Induction of antibody response

Disease associations

DiphtheriaInfection

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