DIS3 mitotic control homolog (S. cerevisiae)-like 2 pseudogene 1 (DIS3L2P1)

DIS3 mitotic control homolog (S. cerevisiae)-like 2 pseudogene 1 (DIS3L2P1) is a human pseudogene, not encoding a functional protein. It is homologous to the protein-coding DIS3L2 gene, which encodes a 3'-5' exonuclease involved in RNA degradation. As a pseudogene, DIS3L2P1 arises from duplication or retrotransposition events, but its sequence is disrupted and does not result in a functional gene product. Pseudogenes like DIS3L2P1 may occasionally have regulatory effects at the RNA level, but such roles (e.g., acting as microRNA decoys) are not established for this locus. There are no known interacting drugs, clinical disease links, or established biomarker roles for this pseudogene. The presence of the "pseudogene" designation means it is not considered a therapeutic target or functional receptor, enzyme, transporter, or related class. The DIS3L2P1 pseudogene is sometimes listed in gene catalogs and product databases—often to clarify it is distinct from the functional DIS3L2 gene. Pseudogenes are classified according to their origin (processed, unprocessed/duplicated, or unitary). DIS3L2P1 appears to be a processed or duplicated pseudogene, lacking protein-coding ability due to accumulated mutations and/or truncations. Canonical name and abbreviation both reference the pseudogene status and its similarity to DIS3L2, but it is not abbreviated as "DIS3L2," which refers to the functional gene.

Other names

DIS3L2PFAM6B