Discoidin domain-containing receptor 1 (DDR1) (DDR1)

Discoidin domain-containing receptor 1 (DDR1) is a unique member of the receptor tyrosine kinase (RTK) family that is activated by various types of collagen rather than soluble growth factors [UniProt Q08345]. Upon collagen binding, DDR1 undergoes slow and sustained autophosphorylation, mediating interactions between cells and the extracellular matrix to regulate cell adhesion, proliferation, and remodeling [PubMed: 29038211]. In pathological contexts, DDR1 is frequently overexpressed in various solid tumors, such as lung and breast cancer, where it promotes cell survival, invasion, and resistance to chemotherapy [PubMed: 30107119]. Beyond oncology, DDR1 signaling is a key driver of fibrotic diseases in the kidney and lungs, as well as chronic inflammation in atherosclerosis, by promoting collagen deposition and cytokine production [PubMed: 28213285]. Consequently, DDR1 has emerged as a promising therapeutic target, with several multi-kinase inhibitors like Nilotinib and selective small molecules being investigated to disrupt its signaling in cancer and fibrotic disorders [PubChem; PubMed: 24107177].

Other names

CD167 antigen-like family member ACell adhesion kinaseEpithelial discoidin domain-containing receptor 1Protein-tyrosine kinase RTK 6Tyrosine kinase DDRMCK10NTRK4PTK3ARTK6TRKE

Inhibition of the intracellular tyrosine kinase domain, preventing autophosphorylation and downstream signaling triggered by collagen binding [PubMed: 24107177].