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DNA (adenine N7 position) (N/A)

Target: N/A
Molecular classification: DNA component, Nucleobase

Overview

The N7 position refers to the nitrogen atom at the seventh position on the adenine base, one of the four nucleobases in DNA. It is a site susceptible to chemical modification, such as alkylation. Alkylation at this site can lead to DNA adduct formation, potentially resulting in miscoding during replication or triggering repair pathways. While not directly involved in base pairing, its accessibility in the major groove makes it available for interaction with proteins or small molecules.

Other names: Adenine N7N7-adenineDNA adenine N7 nitrogen

Mechanism of action

N/A

Biological functions

DNA base pairing (indirectly)Site of chemical modificationMutagenesis (indirectly)DNA damage response (indirectly)

Disease associations

Cancer (indirectly, via mutagenesis)

Safety considerations

Potential for miscoding during replication if modified

Biomarkers

Adenine-N7 adducts (biomarker of exposure to alkylating agents)

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