Target intelligence / Profile preview

DNA (alkylation at O6-guanosine) (None)

Target: None
Molecular classification: DNA, Nucleic acid, Damaged DNA

Overview

DNA alkylation at the O6 position of guanine refers to the covalent attachment of an alkyl group to the oxygen atom at the sixth position of guanine. This modification is a form of DNA damage that can have significant biological consequences, primarily leading to G:C → A:T transition mutations if unrepaired, contributing to mutagenesis, toxicity, and carcinogenesis.

Mechanism of action

DNA alkylation, leading to mispairing and mutations

Biological functions

DNA replicationGenetic information storageBase pairing

Disease associations

CancerMutagenesisCell death

Safety considerations

MutagenicityCarcinogenicityToxicity

Biomarkers

O6-methylguanine levelsMGMT/AGT expression levels

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