Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
- Target
- DNMT3B
- Molecular classification
- Enzyme, DNA methyltransferase
01
Overview
DNMT3B is a DNA methyltransferase enzyme responsible for establishing new DNA methylation patterns during embryonic development. It plays a critical role in normal mammalian development, genomic imprinting, X-chromosome inactivation, and regulation of gene expression. Mutations in DNMT3B are associated with immunodeficiency-centromeric instability-facial anomalies syndrome (ICF) and have been implicated in cancer and other developmental disorders.
- Other names
- DNA methyltransferase 3B
02
Mechanism of action
Catalyzes the transfer of a methyl group to the 5-position of cytosine residues in DNA at CpG dinucleotides, leading to transcriptional repression.
03
Biological functions
DNA methylationDe novo methylationEpigenetic regulationTranscriptional repressionGenomic imprintingX-chromosome inactivationRegulation of gene expressionMaintenance of genome stability
04
Disease associations
Immunodeficiency-centromeric instability-facial anomalies syndrome (ICF)CancerNeurodevelopmental disordersNicotine dependencyDevelopmental disorders
05
Safety considerations
Dysregulation can lead to aberrant DNA methylation patterns and contribute to various diseases.
Beyond the preview
Go deeper on DNA (cytosine-5)-methyltransferase 3B (DNMT3B).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on DNA (cytosine-5)-methyltransferase 3B (DNMT3B).