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Target intelligence / Profile preview
DNA (Double-Stranded B-Form) (DNA)
- Target
- DNA
- Molecular classification
- Nucleic Acid, Genome
01
Overview
Double-stranded B-form DNA is the target for intercalating agents. These agents insert themselves between base pairs, distorting the helical structure and interfering with replication and transcription. This mechanism is exploited in cancer chemotherapy to inhibit cell division. Metallo-intercalators offer potential for enhanced specificity and targeted disruption of DNA.
- Other names
- Deoxyribonucleic AciddsDNA
02
Mechanism of action
Intercalation between base pairs, leading to distortion of the DNA helix and inhibition of DNA and RNA polymerases.
03
Biological functions
Genetic Information StorageReplication TemplateTranscription Template
04
Disease associations
CancerGenetic DisordersInfection
05
Safety considerations
Toxicity to healthy dividing cellsLack of selectivity
06
Interacting drugs
Doxorubicin
4 more in the full profile.
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