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DNA (guanine N7 position) (N/A)
- Target
- N/A
- Molecular classification
- DNA, Nucleobase
01
Overview
The N7 position of guanine in DNA is a highly nucleophilic site and the most reactive location for alkylation or adduct formation by various chemicals. While adducts at this site serve as biomarkers for exposure, they are generally not directly mutagenic due to their instability. Sequence context influences the reactivity of this site.
- Other names
- Guanine N7N7-GuanineGua-N7
02
Mechanism of action
Covalent modification (alkylation/adduct formation) at the N7 position of guanine in DNA.
03
Biological functions
DNA modificationAdduct formationBiomarker of exposure
04
Disease associations
Cancer (exposure related)Toxicology
05
Safety considerations
DNA damageDepurinationPotential for conversion to more mutagenic lesions (e.g., FAPy)Non-specific targeting by alkylating agents
06
Interacting drugs
Nitrogen mustards
3 more in the full profile.
07
Biomarkers
N7-guanine adducts
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