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Target intelligence / Profile preview
DNA (via crosslinking by platinum agent) (DNA-Pt)
- Target
- DNA-Pt
- Molecular classification
- Nucleic Acid, DNA, Other
01
Overview
Platinum-based agents induce DNA crosslinks, forming adducts primarily at guanine and adenine bases. These crosslinks, including intrastrand, interstrand, and DNA-protein crosslinks (DPCLs), distort the DNA helix, block replication and transcription, and ultimately trigger apoptosis. Repair pathways like NER and homologous recombination attempt to remove these lesions, but persistent DPCLs contribute to cytotoxicity.
- Other names
- Platinated DNACisplatin-DNA adductsDNA-Platinum crosslinks
02
Mechanism of action
Covalent binding and crosslinking of DNA by platinum(II) complexes, leading to DNA damage and subsequent cell death.
03
Biological functions
DNA replicationTranscriptionGenome integrityApoptosis inductionCell cycle arrest
04
Disease associations
Cancer
05
Safety considerations
NephrotoxicityNeurotoxicityOtotoxicityMyelosuppressionDrug resistance
06
Interacting drugs
Cisplatin
2 more in the full profile.
07
Biomarkers
ERCC1 expression (predictive of cisplatin resistance)Microsatellite instability (MSI)Homologous recombination deficiency (HRD)
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