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DNA (via platinum-DNA adduct formation) (DNA-Pt Adducts)
- Target
- DNA-Pt Adducts
- Molecular classification
- Nucleic Acid, DNA
01
Overview
Platinum-DNA adducts are covalent complexes formed between DNA and platinum-based anticancer drugs. These adducts, primarily intrastrand cross-links at guanine bases, distort the DNA helix, interfering with replication and transcription. The formation of these adducts leads to cell cycle arrest and apoptosis in cancer cells. Resistance can develop through enhanced DNA repair or reduced drug uptake. Adduct levels serve as potential biomarkers.
- Other names
- Platinum-DNA adductsPt-DNA adductsCisplatin-DNA adductsCarboplatin-DNA adductsOxaliplatin-DNA adductsDNA platination
02
Mechanism of action
Platinum-based drugs form covalent adducts with DNA, primarily at guanine bases, disrupting DNA replication and transcription, leading to cell cycle arrest and apoptosis.
03
Biological functions
DNA replicationDNA transcriptionDNA repairCell cycle regulationApoptosis
04
Disease associations
Cancer
05
Safety considerations
Drug resistance (enhanced DNA repair, reduced drug uptake)Off-target effects (toxicity to normal tissues)Cumulative toxicity
06
Interacting drugs
Cisplatin
2 more in the full profile.
07
Biomarkers
Levels of specific platinum-DNA adducts (e.g., GG-adducts, AG-adducts)Expression levels of nucleotide excision repair (NER) pathway components
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