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DNA Crosslinking (Carboplatin-induced) (N/A)
- Target
- N/A
- Molecular classification
- DNA, DNA adduct
01
Overview
DNA crosslinking, induced by carboplatin, involves the formation of covalent bonds between nucleotides, primarily through platinum-DNA adduct formation. This process disrupts DNA replication and transcription, leading to cell cycle arrest and cell death, making it a target for cancer chemotherapy.
- Other names
- Carboplatin-DNA adductsPlatinum-DNA crosslinksCarboplatin-induced DNA damage
02
Mechanism of action
Carboplatin enters cells, hydrolyzes to form a reactive platinum complex, and covalently binds to DNA, primarily at the N7 position of guanine and adenine bases. This forms DNA adducts, including intrastrand and interstrand crosslinks, distorting the DNA structure and inhibiting replication and transcription. This ultimately leads to cell cycle arrest and apoptosis.
03
Biological functions
DNA replication inhibitionTranscription inhibitionDNA damage responseCell cycle arrestApoptosis inductionCell death
04
Disease associations
Cancer
05
Safety considerations
Resistance development (e.g., increased NER)Off-target effects leading to toxicity
06
Interacting drugs
Carboplatin
2 more in the full profile.
07
Biomarkers
HMGB1 expression/binding affinityNucleotide excision repair (NER) activityMismatch repair (MMR) status
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