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DNA Crosslinking (Oxaliplatin)
- Molecular classification
- DNA, Other
01
Overview
DNA crosslinking, as induced by oxaliplatin, refers to the formation of covalent bonds between two nucleotides within DNA, either within the same strand (intrastrand) or between opposite strands (interstrand). Oxaliplatin is a platinum-based chemotherapeutic agent that exerts its cytotoxic effects primarily through this mechanism, leading to disruption of DNA replication and transcription, ultimately triggering cell cycle arrest and apoptosis. The bulky DACH ligand distinguishes oxaliplatin-induced DNA adducts from those formed by other platinum agents, influencing repair protein interactions and resistance profiles.
- Other names
- Oxaliplatin-induced DNA adductsOxaliplatin-DNA crosslinks
02
Mechanism of action
Forms DNA crosslinks (intrastrand and interstrand) primarily at guanine N7 positions, blocking replication and transcription.
03
Biological functions
DNA replication inhibitionTranscription inhibitionApoptosis inductionCell cycle arrest
04
Disease associations
Cancer
05
Safety considerations
Interindividual variability in adduct formation and repairResistance development via NER or other mechanisms
06
Interacting drugs
Oxaliplatin
07
Biomarkers
Alkaline comet assay resultsDNA adduct levels
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