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DNA Crosslinking (Platinum Adducts)

Molecular classification: DNA, DNA Adduct

Overview

DNA crosslinking via platinum adduct formation is central to the mechanism by which several key chemotherapeutics exert cytotoxic effects against cancer cells. By forming stable intra/interstrand links—and occasionally ternary protein-DNA-platinum complexes—these drugs induce structural distortions that overwhelm cellular repair systems leading ultimately to cell death.

Mechanism of action

Covalent binding to DNA, forming intra- and interstrand crosslinks, disrupting DNA replication and transcription, and inducing apoptosis.

Biological functions

Cell cycle arrestApoptosis inductionDNA replication inhibitionTranscription inhibition

Disease associations

Cancer

Safety considerations

NeurotoxicityDrug resistance

Interacting drugs

Cisplatin

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