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Target intelligence / Profile preview
DNA Crosslinking via Platinum Agent (Oxaliplatin)
- Molecular classification
- DNA, Other
01
Overview
DNA crosslinking via platinum agents refers to the process by which platinum-based chemotherapy drugs, such as oxaliplatin, form covalent bonds between DNA strands or between DNA and proteins. This disrupts essential cellular processes like replication and transcription, ultimately leading to cell death. Oxaliplatin primarily forms intrastrand crosslinks at guanine and adenine bases.
02
Mechanism of action
Covalent binding to DNA, forming intra- and interstrand crosslinks, disrupting replication and transcription.
03
Biological functions
DNA replication inhibitionTranscription inhibitionApoptosis inductionCell death
04
Disease associations
Cancer
05
Safety considerations
Resistance development due to enhanced NER activityMismatch repair deficiency impact (less than cisplatin)Potential for off-target effects
06
Interacting drugs
Oxaliplatin
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