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Target intelligence / Profile preview
DNA-dependent enzyme topoisomerase II (TopoII)
- Target
- TopoII
- Molecular classification
- Enzyme, Type IIA topoisomerase
01
Overview
DNA-dependent enzyme topoisomerase II (Topo II) is a large, ATP-dependent homodimeric enzyme found in all eukaryotes and many prokaryotes. It plays a critical role in managing the topological states of DNA during essential cellular processes such as replication, transcription, recombination, and chromosome segregation. It alters DNA topology by introducing transient double-stranded breaks in the DNA helix to resolve supercoiling, knots, and tangles. Topo II is a major target for anticancer drugs.
- Other names
- Topoisomerase IITop2
02
Mechanism of action
Stabilizes covalent enzyme-DNA intermediates, leading to double-strand breaks; catalytic inhibition.
03
Biological functions
Resolves supercoilsResolves knotsResolves catenanesDNA replicationTranscriptionChromosome segregationDNA repair
04
Disease associations
CancerGenomic instability
05
Safety considerations
Off-target toxicity in normal proliferating tissues
06
Interacting drugs
Etoposide
1 more in the full profile.
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