DNA-dependent enzyme topoisomerase II (TopoII)

DNA-dependent enzyme topoisomerase II Overview

DNA-dependent enzyme topoisomerase II (Topo II) is a large, ATP-dependent homodimeric enzyme found in all eukaryotes and many prokaryotes. It plays a critical role in managing the topological states of DNA during essential cellular processes such as replication, transcription, recombination, and chromosome segregation. It alters DNA topology by introducing transient double-stranded breaks in the DNA helix to resolve supercoiling, knots, and tangles. Topo II is a major target for anticancer drugs.

Mechanism of Action

Stabilizes covalent enzyme-DNA intermediates, leading to double-strand breaks; catalytic inhibition.

Biological Functions

Safety Considerations

Interacting Drugs