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Target intelligence / Profile preview
DNA double-strand break induction via alpha-particle emission (actinium-225) (DSB (α-²²µAc))
- Target
- DSB (α-²²µAc)
- Molecular classification
- Genomic/Nuclear DNA, DNA damage
01
Overview
DNA double-strand break induction via alpha-particle emission (actinium-225) describes the mechanism by which actinium-225 radiopharmaceuticals exert their therapeutic effect. Actinium-225 decays, emitting alpha particles that induce clustered double-strand breaks (DSBs) in the DNA of targeted cells, leading to cell death through apoptosis or senescence.
- Other names
- Actinium-225 induced DNA damage²²µAc-induced DSBsAlpha-particle induced DNA double-strand breaks
02
Mechanism of action
Induction of clustered double-strand breaks via high LET α-particles emitted during actinium-225 decay.
03
Biological functions
DNA damage response (DDR)Cell cycle arrestApoptosisSenescenceCell death
04
Disease associations
Cancer
05
Safety considerations
Off-target radiation damageDose-limiting toxicities to healthy tissuesPotential for resistance development
06
Interacting drugs
Actinium-225 radiopharmaceuticals (e.g., ²²µAc-DOTATOC)
07
Biomarkers
γH2AX foci
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