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Target intelligence / Profile preview
DNA Double-Strand Breaks (Actinium-225-Mediated) (DSBs (^225Ac))
- Target
- DSBs (^225Ac)
- Molecular classification
- DNA, Radiation-induced damage
01
Overview
Actinium-225-mediated targeted therapy induces DNA double-strand breaks (DSBs) in tumor cells through the emission of high-energy, short-range alpha particles. These particles cause localized and irreparable DNA damage, leading to cell death. This approach is particularly effective against refractory malignancies due to its potency and ability to overcome resistance mechanisms.
- Other names
- Actinium-225 induced DNA damage^225Ac-mediated DNA DSBsAlpha particle-induced DNA breaks
02
Mechanism of action
High-energy alpha particle emission inducing irreparable DNA double-strand breaks.
03
Biological functions
Cell death inductionDNA damage responseTumor suppression
04
Disease associations
Cancer therapyTreatment of refractory malignancies
05
Safety considerations
Off-target toxicityRadiation-induced side effectsDelivery optimization
06
Interacting drugs
^225Ac-labeled antibodies
1 more in the full profile.
07
Biomarkers
γH2AX stainingApoptosis markers
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