DNA gyrase subunit A (None)

DNA gyrase subunit A Overview

DNA gyrase subunit A (GyrA) is one of the two essential protein components of bacterial DNA gyrase, a type II topoisomerase unique to prokaryotes. DNA gyrase introduces negative supercoils into closed circular double-stranded DNA in an ATP-dependent manner, which is critical for processes such as replication, transcription, and recombination. The enzyme is a heterotetramer composed of two GyrA and two GyrB subunits (A₂B₂ complex). GyrA is the target of fluoroquinolone antibiotics.

Mechanism of Action

Inhibition of DNA religation after cleavage by binding at or near the active site

Biological Functions

Safety Considerations

Interacting Drugs