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Target intelligence / Profile preview
DNA gyrase subunit A (None)
- Target
- None
- Molecular classification
- Enzyme, Type II topoisomerase
01
Overview
DNA gyrase subunit A (GyrA) is one of the two essential protein components of bacterial DNA gyrase, a type II topoisomerase unique to prokaryotes. DNA gyrase introduces negative supercoils into closed circular double-stranded DNA in an ATP-dependent manner, which is critical for processes such as replication, transcription, and recombination. The enzyme is a heterotetramer composed of two GyrA and two GyrB subunits (A₂B₂ complex). GyrA is the target of fluoroquinolone antibiotics.
02
Mechanism of action
Inhibition of DNA religation after cleavage by binding at or near the active site
03
Biological functions
DNA supercoilingDNA relaxationChromosome compactionReplicationTranscriptionRecombination
04
Disease associations
Infection
05
Safety considerations
Antibacterial resistance
06
Interacting drugs
Fluoroquinolones
1 more in the full profile.
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