Molecular Classification
Other
Disease Roles
CancerOther

DNA Intercalator Overview

A DNA intercalator is a molecule, typically small and planar, that binds to DNA by inserting itself between adjacent base pairs of the double helix. This binding mode is distinct from other types of DNA interactions. The process of intercalation causes structural changes in the DNA, including unwinding and elongation of the helix, which can disrupt normal biological functions such as replication and transcription.

Mechanism of Action

Interacts with nucleic acids via planar insertion between base pairs, disrupting DNA structure and function.

Biological Functions

DNA binding
Inhibition of DNA replication
Inhibition of transcription

Disease Associations

Cancer
Other

Safety Considerations

  • Lack of therapeutic specificity
  • Potential for off-target effects
  • Induction of DNA damage

Interacting Drugs

Ethidium bromide
Proflavine
Daunomycin (Daunorubicin)
Doxorubicin (Adriamycin)
Berberine
Thalidomide
Dactinomycin