DNA Polymerase Alpha (POLA)

DNA Polymerase Alpha Overview

DNA polymerase alpha (POLA) is a key enzyme complex in eukaryotic DNA replication, responsible for initiating the synthesis of new DNA strands during cell division. It functions as part of a four-subunit complex known as the alpha DNA polymerase-primase complex, which consists of POLA1 (catalytic), POLA2 (regulatory), PRIM1, and PRIM2 (primases). Its primary role is to generate chimeric RNA–DNA primers at origins of replication and Okazaki fragment start sites.

Mechanism of Action

Inhibition of DNA Polymerase Alpha activity, preventing DNA replication and cell proliferation.

Biological Functions

Safety Considerations