Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
DNA Polymerase Alpha (POLA)
- Target
- POLA
- Molecular classification
- Enzyme, DNA Polymerase
01
Overview
DNA polymerase alpha (POLA) is a key enzyme complex in eukaryotic DNA replication, responsible for initiating the synthesis of new DNA strands during cell division. It functions as part of a four-subunit complex known as the alpha DNA polymerase-primase complex, which consists of POLA1 (catalytic), POLA2 (regulatory), PRIM1, and PRIM2 (primases). Its primary role is to generate chimeric RNA–DNA primers at origins of replication and Okazaki fragment start sites.
02
Mechanism of action
Inhibition of DNA Polymerase Alpha activity, preventing DNA replication and cell proliferation.
03
Biological functions
DNA replication initiationRNA-DNA primer synthesisCell cycle
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to involvement in essential cellular processes.Development of resistance mechanisms.
Beyond the preview
Go deeper on DNA Polymerase Alpha (POLA).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on DNA Polymerase Alpha (POLA).