DNA polymerase epsilon 2, accessory subunit (POLE2)

DNA polymerase epsilon 2, accessory subunit (POLE2), is the small (B) non-catalytic subunit of the DNA polymerase epsilon complex, an essential multi-subunit enzyme responsible for leading strand DNA synthesis during chromosomal DNA replication and DNA repair in eukaryotic cells[2][6][9]. POLE2 plays an accessory role, stabilizing the polymerase complex and contributing to its assembly and function. Mutations or altered expression of POLE2 have been implicated in a range of malignancies, where the gene is often overexpressed and promotes tumorigenic phenotypes by supporting enhanced DNA replication and cell proliferation[1][7]. Loss-of-function experiments show that reduced POLE2 expression impairs tumor growth and increases cell sensitivity to apoptosis. Defects in POLE2 are also associated with immunodeficiency and other genetic diseases. No approved drugs currently target POLE2 directly, but its involvement in cancer highlights its potential value for molecular therapy and as a prognostic biomarker[1][7][9].

Other names

DNA polymerase epsilon subunit 2DPE2DNA polymerase II subunit 2DNA polymerase epsilon subunit Bpolymerase (DNA directed), epsilon 2 (p59 subunit)polymerase (DNA directed), epsilon 2, accessory subunitpolymerase (DNA) epsilon 2, accessory subunit

Inhibition or modulation of DNA polymerase epsilon activity may suppress DNA replication and repair in proliferating cells, leading to antitumor effects (inferred from biological function; no current drugs are directly known to target POLE2 specifically)