Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
DNA polymerase epsilon 3, accessory subunit (POLE3)
- Target
- POLE3
- Molecular classification
- Enzyme, Chromatin-associated protein, Other
01
Overview
DNA polymerase epsilon 3, accessory subunit (POLE3) is a histone-fold protein that forms part of the DNA polymerase epsilon complex, an essential enzyme for chromosomal DNA replication and repair. POLE3 interacts with other histone-fold proteins to bind DNA in a sequence-independent manner and aids in the incorporation of naked DNA into chromatin, a process assisted by nucleosome-remodeling factors. POLE3’s accessory function is required for proper DNA repair, genome stability, and regulated chromatin packaging during cell division and transcription, and it forms a structural scaffold within the larger DNA polymerase epsilon holoenzyme.
- Other names
- CHRAC17CHARAC17CHRAC2YBL1p17DNA polymerase epsilon p17 subunitDNA polymerase epsilon subunit p17DNA polymerase II subunit 3Arsenic transactivated protein (AsTP)Chromatin accessibility complex 17 kDa proteinChromatin accessibility complex subunit 2Histone fold protein CHRAC17HuCHRAC17
02
Biological functions
DNA replicationDNA repairChromatin binding and packagingTranscription regulationProtein-protein interactions
03
Disease associations
CancerOther
Beyond the preview
Go deeper on DNA polymerase epsilon 3, accessory subunit (POLE3).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on DNA polymerase epsilon 3, accessory subunit (POLE3).