DNA Replication and Repair Enzymes ()

DNA Replication and Repair Enzymes Overview

DNA replication and repair enzymes are essential proteins that maintain the integrity and stability of genetic information in all living organisms. These enzymes are responsible for accurately copying DNA during cell division (replication) and correcting any errors or damage that occur to the DNA molecule (repair). Their coordinated action ensures faithful transmission of genetic material from one generation to the next and protects cells from mutations that could lead to disease, including cancer. Key enzymes include DNA polymerases, helicases, ligases, mismatch repair enzymes, nucleotide excision repair enzymes, and double-strand break repair enzymes. Deficiencies or malfunctions in these enzymes can result in increased mutation rates or genomic instability.

Mechanism of Action

Varies depending on the specific enzyme. Examples include: Inhibition of DNA polymerase activity, disruption of helicase unwinding, preventing ligation, inhibiting PARP activity.

Biological Functions

Safety Considerations