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DNA Synthesis (Incorporation as Fraudulent Nucleotide)
- Molecular classification
- Other
01
Overview
DNA synthesis is the process by which new DNA strands are formed. The target "DNA synthesis (incorporation as fraudulent nucleotide)" refers to the deliberate or accidental incorporation of non-canonical, synthetic, or analog nucleotides into newly synthesized DNA in place of natural bases. This can occur through exposure to certain drugs or experimental probes and has significant implications for mutagenesis, cytotoxicity, and therapeutic intervention. Fraudulent nucleotide incorporation is exploited therapeutically in anticancer and antiviral agents.
- Other names
- Fraudulent Nucleotide IncorporationNucleotide Analog IncorporationDNA Replication InterferenceAntimetabolite Incorporation
02
Mechanism of action
Mimicry/substitution for natural bases by cellular/viral polymerases; may cause chain termination, mutation, or activation of DNA repair pathways.
03
Biological functions
DNA replicationMutagenesisCell deathAntiviral activityAnticancer activity
04
Disease associations
CancerInfection
05
Safety considerations
MutagenesisCytotoxicityPotential for off-target effects
06
Interacting drugs
6-mercaptopurine (6-MP)
5 more in the full profile.
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