DNAAF4-CCPG1 readthrough (non-protein coding) (DNAAF4-CCPG1)

The DNAAF4-CCPG1 readthrough locus represents a naturally occurring transcriptional readthrough between two neighboring genes on chromosome 15: *Dyslexia susceptibility 1 candidate 1* (DYX1C1, also known as DNAAF4) and *Cell cycle progression 1* (CCPG1). This transcript is classified as a candidate for *nonsense-mediated mRNA decay (NMD)*, which means it is rapidly degraded in cells and is unlikely to yield a functional protein product. It is considered a non-coding RNA of the long non-coding RNA (lncRNA) class and is not a therapeutic target or functional receptor, enzyme, or transporter. Diseases associated with this region are due to mutations in the underlying functional neighboring genes (DYX1C1/DNAAF4—for ciliary dyskinesia and reading disability/dyslexia, CCPG1—for autophagy/ER-phagy), but not the readthrough transcript itself[1]. This target is not a functional molecule itself but an annotation reflecting an intergenic readthrough transcript that is subjected to decay, with no known protein product or direct role in drug targeting, signaling, or disease mechanism[1]. Any biological/disease relevance is due to defects in the component genes, not the noncoding readthrough.

Other names

DYX1C1-CCPG1DYX1C1-CCPG1 readthrough (NMD candidate)DYX1C1-CCPG1 readthrough (non-protein coding)