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Target intelligence / Profile preview
DnaJ heat shock protein family (Hsp40) member A3 (DNAJA3)
- Target
- DNAJA3
- Molecular classification
- Molecular chaperone, DNAJ/Hsp40 protein family
01
Overview
DNAJA3 encodes a member of the DNAJ/Hsp40 protein family, acting as a molecular chaperone that stimulates Hsp70 ATPase activity. It plays critical roles in protein folding, mitochondrial function, apoptosis regulation, tumor suppression, and antiviral response. It exists as long (pro-apoptotic) and short (anti-apoptotic) isoforms, influencing mitochondrial dynamics and cell fate decisions. Its interactions with oncogenic proteins and tumor suppressors highlight its significance in cancer biology.
- Other names
- TID1Tumorous imaginal disc 1 homolog
02
Mechanism of action
Modulates Hsp70 ATPase activity, regulates mitochondrial dynamics and apoptosis pathways, interacts with oncogenic proteins and tumor suppressors, induces autophagy for antiviral defense.
03
Biological functions
Protein foldingProtein degradationAssembly of multiprotein complexesMitochondrial membrane potential maintenancemtDNA integrity maintenanceRegulation of mitochondrial complex I aggregationMitochondrial fission (via DRP1)Regulation of cell movementRegulation of cell growthRegulation of cell proliferationRegulation of cell differentiationRegulation of cell senescenceRegulation of apoptosisTumor suppressionAutophagyAntiviral response
04
Disease associations
CancerViral infection
05
Safety considerations
Dysregulation can lead to aberrant apoptosis and contribute to cancer development.Isoform-specific effects on apoptosis require careful consideration.
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