DnaJ heat shock protein family (Hsp40) member B1 (DNAJB1)

DnaJ heat shock protein family (Hsp40) member B1 (DNAJB1) is a molecular chaperone belonging to the DnaJ/Hsp40 family, characterized by a conserved J-domain and primarily functioning to regulate the activity of Hsp70 heat shock proteins. DNAJB1 assists in protein folding, prevents aggregation of misfolded proteins, and is critical in cellular stress responses by stimulating the ATPase activity of Hsp70 chaperones. DNAJB1 interacts with several partners, including HSP70, HSPA4, and STUB1, and plays a role in a wide range of cellular processes involving protein quality control. The DNAJB1-PRKACA gene fusion product acts as a potent oncogenic driver specific to fibrolamellar carcinoma, making it an important diagnostic and therapeutic biomarker for this cancer subtype.

Other names

DnaJ homolog subfamily B member 1DNAJ1HDJ1HSPF1HSP40Heat shock protein 40hDj-1Sis1RSPH16BDnaJ protein homolog 1Heat shock 40 kDa protein 1Human DnaJ protein 1radial spoke 16 homolog B (Chlamydomonas)

Not applicable for direct drug targeting; its disease involvement is typically via chaperone function modulation or oncogenic fusion (as in DNAJB1-PRKACA)