DnaJ heat shock protein family (Hsp40) member C27 (DNAJC27)

DnaJ heat shock protein family (Hsp40) member C27 (DNAJC27) is a member of the Hsp40/DnaJ co-chaperone families, predicted to function as a small Ras-like GTPase. It is involved in intracellular protein transport and is located in the cytoplasm, cytoplasmic vesicles, and nucleus[1][2][6][7]. DNAJC27 has been shown to activate the MEK/ERK pathway, potentially by serving as a nuclear scaffold for MAPK1/ERK2, thus enhancing ERK signaling and influencing cell transformation when overexpressed[2][3]. Genome-wide association studies indicate that variants in or near DNAJC27 are linked to variation in human body mass index, supporting a role in energy metabolism and obesity susceptibility[1]. Elevated circulating DNAJC27 is seen in obese individuals and patients with type 2 diabetes, suggesting a possible contributory role in these metabolic diseases[1]. There is no current evidence that DNAJC27 is a direct therapeutic target or druggable protein, but its function at the interface of stress response and metabolism makes it of interest for further research into metabolic and stress-related diseases[1][2][6].

Other names

RBJRABJSRabJSRab and DnaJ domain-containing proteinDnaJ homolog subfamily C member 27