Dolichyl-phosphate mannosyltransferase subunit 1, catalytic (DPM1)

Dolichyl-phosphate mannosyltransferase subunit 1, catalytic (DPM1), is the catalytic component of the dolichyl-phosphate mannose (DPM) synthase enzyme complex, which is responsible for transferring mannose from GDP-mannose to dolichol monophosphate to produce dolichol-phosphate mannose (Dol-P-Man) on the cytosolic side of the endoplasmic reticulum (ER)[1][5][6]. Dol-P-Man serves as a crucial donor for mannosyl residues in several glycosylation processes, including N-glycosylation, GPI-anchor biosynthesis, and O-mannosylation of proteins. DPM1 is essential for normal cell function and development; genetic deficiencies cause congenital disorders of glycosylation. DPM1 lacks a transmembrane domain and is regulated by additional subunits DPM2 and DPM3 that assist in ER localization and complex stability[3][5].

Other names

DPM1Dolichyl-phosphate beta-D-mannosyltransferase subunit 1Dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunitDolichol-phosphate mannosyltransferase subunit 1Dolichol-phosphate mannose synthase subunit 1CDGIEMPDSMannose-P-dolichol synthase subunit 1DPM synthase subunit 1MPD synthase subunit 1EC 2.4.1.83[5][9]