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Dopamine Receptor (Mesolimbic) (N/A)
- Target
- N/A
- Molecular classification
- G protein-coupled receptor
01
Overview
Dopamine receptors located within the mesolimbic pathway, a key dopaminergic circuit in the brain. These receptors, primarily G protein-coupled receptors, mediate the effects of dopamine, a neurotransmitter crucial for reward, motivation, and reinforcement learning. The main subtypes expressed in this region are D1-like (D1, D5) and D2-like (D2, D3, D4) dopamine receptors. Dysregulation or abnormal signaling through these receptors/pathways is implicated in addiction, schizophrenia, ADHD, depression, and chronic pain.
- Other names
- Mesolimbic Dopamine ReceptorReward Pathway Dopamine ReceptorVTA Dopamine ReceptorNucleus Accumbens Dopamine Receptor
02
Mechanism of action
Agonism, antagonism, or modulation of dopamine receptor signaling in the mesolimbic pathway.
03
Biological functions
Signal transductionReward processingMotivationReinforcement learningIncentive salienceMotor function learningEmotional regulation
04
Disease associations
AddictionSchizophreniaADHDDepressionChronic pain
05
Safety considerations
Extrapyramidal symptoms (EPS)Tardive dyskinesiaNeuroleptic malignant syndromeCardiovascular effectsRisk of addictionPsychosis
06
Interacting drugs
Antipsychotics
3 more in the full profile.
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