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Target intelligence / Profile preview
Dopamine Receptor D(3) (DRD3)
- Target
- DRD3
- Molecular classification
- G protein-coupled receptor, GPCR, Receptor
01
Overview
The D(3) dopamine receptor (DRD3) is a G protein-coupled receptor that primarily inhibits adenylyl cyclase, reducing cAMP levels. It is predominantly expressed in the ventral striatum, thalamus, hippocampus, and cortex. DRD3 modulates dopaminergic neurotransmission and regulates neuronal excitability. It is implicated in schizophrenia, Parkinson's disease, drug addiction, and depression and is considered a promising therapeutic target.
- Other names
- D3 dopamine receptor
02
Mechanism of action
Agonism or antagonism/partial agonism of the dopamine D3 receptor, modulating downstream signaling pathways involving cAMP and neuronal excitability.
03
Biological functions
Signal transductionModulation of dopaminergic neurotransmissionRegulation of neuronal excitabilityInhibition of adenylyl cyclase
04
Disease associations
SchizophreniaParkinson's diseaseDrug addictionDepression
05
Interacting drugs
Pramipexole
4 more in the full profile.
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