Dopamine receptor D1, Dopamine receptor D3, Dopamine receptor D4 (DRD1, DRD3, DRD4)

Dopamine receptor D1, D3, and D4 are three members of the dopamine receptor family within the G protein-coupled receptor superfamily. D1 is part of the D1-like group, coupled to Gs proteins and generally stimulates cAMP production; D3 and D4 are in the D2-like group, coupled to Gi/o proteins and inhibit cAMP signaling[1][2][3][5][6]. These receptors are differentially localized in the brain: D1 is widely expressed throughout the CNS, D3 and D4 show more selective expression patterns, especially D4 in the prefrontal cortex and hippocampus[4][5]. They play key roles in neurophysiology, including regulation of motor activity, reward, cognition, and emotion. Dysfunction or altered signaling of these receptors is implicated in several neurological and psychiatric conditions, and they are important therapeutic targets for drugs treating disorders such as schizophrenia, Parkinson’s disease, and attention deficit disorders[1][2][4][5][6].

Other names

D1 receptorD-1 receptorDA D1 receptorD3 receptorD-3 receptorDA D3 receptorD4 receptorD-4 receptorDA D4 receptor

Antagonism (blockade) or agonism (stimulation) of dopamine receptors to modulate downstream G protein signaling (Gs for D1, Gi/o for D3, D4) Regulation of cAMP levels via G protein coupling (D1 increases cAMP, D3/D4 decrease cAMP)