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Target intelligence / Profile preview
Dopamine Receptor D2 (Gut) (DRD2)
- Target
- DRD2
- Molecular classification
- GPCR, G protein-coupled receptor, D₂-like dopamine receptor subfamily
01
Overview
Dopamine receptor D2 (DRD2) is a G protein-coupled receptor (GPCR) that primarily couples to the Gi subtype of G proteins, leading to inhibition of adenylyl cyclase activity. While DRD2 is well-known for its roles in the central nervous system, it also has significant functions in the gastrointestinal (GI) tract, including motility regulation, secretion/absorption modulation, and mucosal protection. Recent research highlights its role in colonization resistance via sensing microbial tryptophan metabolites. It is expressed in both mucosal tissues and muscular layers of the GI tract.
02
Mechanism of action
Gi protein-coupled receptor activation leading to inhibition of adenylyl cyclase activity.
03
Biological functions
Signal transductionMotility regulationSecretion modulationAbsorption modulationCytoprotectionMucosal defenseHost-microbe interactionColonization resistanceAromatic amino acid metabolite sensor
04
Disease associations
InfectionInflammatory bowel diseasesStress-induced ulcers
05
Safety considerations
Side effects associated with antipsychotics targeting DRD2Potential for off-target effects in the CNS
06
Interacting drugs
Antipsychotics
2 more in the full profile.
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