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Target intelligence / Profile preview
Dopamine Receptor D2 (Postsynaptic) (D2R)
- Target
- D2R
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
The dopamine receptor D2 (D2R) is a G protein-coupled receptor (GPCR) that mediates dopaminergic neurotransmission, particularly within the central nervous system. The postsynaptic D2 receptor couples to Gi/o proteins, inhibiting adenylyl cyclase activity and decreasing cyclic AMP levels. It plays a key role in regulating neurotransmitter release, synaptic plasticity, motor control, reward processing, and is a major target for antipsychotic drugs. Alterations in postsynaptic D2R signaling are implicated in schizophrenia, Parkinson’s disease, drug addiction, and ADHD.
- Other names
- Dopamine Receptor D₂D2 ReceptorDRD2D2L (Long isoform)
02
Mechanism of action
Antagonism or agonism of the dopamine D2 receptor, influencing downstream signaling pathways.
03
Biological functions
Signal transductionInhibition of neuronal excitabilityRegulation of neurotransmitter releaseModulation of synaptic plasticityMotor controlReward processingFiltering sensory/motor information
04
Disease associations
SchizophreniaParkinson’s diseaseDrug addictionAttention deficit hyperactivity disorder (ADHD)
05
Safety considerations
Extrapyramidal side effects (EPS)Tardive dyskinesiaNeuroleptic malignant syndrome
06
Interacting drugs
Antipsychotics
2 more in the full profile.
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