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Target intelligence / Profile preview
Dopamine Receptor D2 (Presynaptic) (D2R (Presynaptic))
- Target
- D2R (Presynaptic)
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
The presynaptic dopamine D2 receptor (primarily the D2S isoform) serves as a critical autoreceptor that regulates multiple aspects of dopaminergic neurotransmission, including dopamine synthesis, release, and reuptake. Its dysfunction is implicated in various neuropsychiatric disorders, making it an important target for therapeutic intervention.
- Other names
- Presynaptic D2 ReceptorD2 AutoreceptorD2S Receptor
02
Mechanism of action
Agonists, antagonists, and partial agonists at the D2 receptor modulate dopamine synthesis and release. Antipsychotics primarily act as D2 receptor antagonists.
03
Biological functions
Regulation of dopamine releaseRegulation of dopamine synthesisRegulation of dopamine reuptakeSignal transductionAutoreceptor function
04
Disease associations
SchizophreniaParkinson's DiseaseAddiction
05
Safety considerations
Extrapyramidal symptoms (EPS) with D2 receptor antagonistsTardive dyskinesia with long-term antipsychotic use
06
Interacting drugs
Antipsychotics
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