DPYD antisense RNA 2 (non-protein coding) (DPYD-AS2)

DPYD antisense RNA 2 (DPYD-AS2) is a long non-coding, natural antisense RNA gene located in the DPYD genomic locus. It is processed in two or three transcript variants on the forward DNA strand and does not encode a protein. DPYD-AS2 is part of a complex regulatory RNA network that modulates DPYD gene expression at the transcriptional and possibly post-transcriptional level. The DPYD gene encodes dihydropyrimidine dehydrogenase, a key enzyme for pyrimidine and chemotherapeutic drug metabolism. Disorders in DPYD regulation—potentially mediated by antisense RNAs like DPYD-AS2—can contribute to disease phenotypes such as enzyme deficiency and severe adverse drug reactions to fluoropyrimidines. While antisense RNAs in general are being investigated as cancer therapy targets, DPYD-AS2 itself is not yet a therapeutic target but represents a candidate for research into regulatory mechanisms and disease-modifying effects.

Other names

DPYD antisense RNA 2DPYD-AS2DPYD antisense RNA 2 (non-protein coding)

Antisense RNA-mediated regulation of DPYD gene expression, possibly affecting enzyme levels and drug metabolism