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Ebolavirus Glycoprotein (GP) Glycan Cap Region
- Molecular classification
- Glycoprotein Region, Glycan Shield
01
Overview
The glycan cap is a heavily glycosylated region of the ebolavirus envelope glycoprotein (GP) GP1 subunit. It sits between the receptor-binding domain (RBD) and the mucin-like domain (MLD), forming part of a 'chalice' structure. Its primary function is to shield critical functional domains from recognition by host antibodies, contributing to immune evasion. It is also involved in viral entry and is a major target for neutralizing antibodies derived from survivors.
- Other names
- Glycan capEBOV GP Glycan CapEbolavirus GP1 Glycan Cap
02
Mechanism of action
Antibodies targeting the glycan cap can neutralize the virus by blocking conformational changes required for fusion or promoting clearance via Fc-mediated mechanisms.
03
Biological functions
Immune evasionModulation of viral entryShielding of functional domains
04
Disease associations
InfectionEbola Virus Disease (EVD)
05
Safety considerations
Evasion of antibody responses due to glycan shieldingTherapeutic challenges due to glycosylation heterogeneity
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