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Target intelligence / Profile preview
Cluster of Differentiation 73 (CD73)
- Target
- CD73
- Molecular classification
- Ecto-enzyme, Cell surface marker, Glycosylphosphatidylinositol (GPI)-anchored protein
01
Overview
Cluster of Differentiation 73 (CD73), also known as ecto-5'-nucleotidase, is a glycosylphosphatidylinositol (GPI)-anchored cell surface enzyme encoded by the NT5E gene. It catalyzes the dephosphorylation of extracellular adenosine monophosphate (AMP) to adenosine, playing a critical role in purinergic signaling pathways that regulate inflammation, immune regulation, and disease pathogenesis. It is a therapeutic target in cancer and other diseases.
- Other names
- Ecto-5'-nucleotidaseNT5E
02
Mechanism of action
Inhibition of CD73 enzymatic activity, blocking adenosine production and downstream immunosuppressive effects. Disrupting tumor metabolic fitness by impairing mitochondrial respiration/aspartate biosynthesis pathways.
03
Biological functions
Purinergic signalingImmune suppression/modulationAdenosine productionTissue homeostasisBarrier protection
04
Disease associations
CancerFibrosisIschemia-Reperfusion InjuryArterial calcifications due to deficiency of CD73
05
Safety considerations
Potential for off-target effects due to widespread CD73 expressionImmune-related adverse events
06
Interacting drugs
Small molecule inhibitors of CD73
1 more in the full profile.
07
Biomarkers
CD73 expression levels in tumor tissueCD73 expression levels on immune cells
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