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Target intelligence / Profile preview
Ectonucleotidase 5'-nucleotidase (CD73)
- Target
- CD73
- Molecular classification
- Enzyme, Ectonucleotidase
01
Overview
CD73, also known as ecto-5'-nucleotidase or NT5E, is a glycosylphosphatidylinositol (GPI)-anchored cell surface enzyme that plays a central role in purine metabolism and extracellular adenosine production. It catalyzes the dephosphorylation of extracellular adenosine monophosphate (AMP) to adenosine, modulating immune responses, vascular integrity, and neuronal activity. Inhibition of CD73 is explored as a therapeutic strategy to enhance anti-tumor immune responses.
- Other names
- NT5EEcto-5'-nucleotidase
02
Mechanism of action
Inhibition/blockade of CD73 enzymatic activity to reduce immunosuppressive adenosine levels.
03
Biological functions
Adenosine production & signalingImmune regulationEpithelial transport/barrier functionsInhibition of endothelial permeabilitySmooth muscle relaxationModulation of neuronal activity
04
Disease associations
CancerInflammatory diseasesAutoimmune diseasesChronic inflammatory conditions
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