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Efferocytosis (Apoptotic cell engulfment)
- Molecular classification
- Other
01
Overview
Efferocytosis is}
- Other names
- Apoptotic cell clearanceProgrammed cell removalPhagocytosis of apoptotic cellsEngulfment of apoptotic cells
02
Mechanism of action
Modulation of "eat-me" (e.g., Phosphatidylserine) and "don't-eat-me" (e.g., CD47) signaling pathways to regulate the phagocytic clearance of cells by macrophages and dendritic cells.
03
Biological functions
ApoptosisImmune responseCell deathPhagocytosisTissue homeostasis
04
Disease associations
CancerInflammationAutoimmune diseaseCardiovascular diseaseNeurodegenerative disease
05
Safety considerations
AnemiaThrombocytopeniaAutoimmunityOff-target phagocytosis of healthy cells
06
Interacting drugs
Magrolimab
6 more in the full profile.
07
Biomarkers
CD47 expressionMerTK expressionAnnexin V bindingSIRPα expressionCalreticulin expression
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