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Elastase (Pseudomonas aeruginosa) (LasB)
- Target
- LasB
- Molecular classification
- Metalloprotease, Enzyme
01
Overview
Elastase from Pseudomonas aeruginosa (LasB) is a zinc-dependent metalloprotease and a major virulence factor secreted by this bacterium. It degrades structural proteins, disrupts cellular junctions, and modulates host immune responses, contributing to tissue damage and infection establishment. LasB is an attractive target for anti-infective drug development.
- Other names
- PseudolysinElastase B
02
Mechanism of action
Inhibition of metalloprotease activity, blocking degradation of elastin and pro-inflammatory cytokines
03
Biological functions
Extracellular matrix degradationProtein degradationImmune evasionTissue damageModulation of host immune responses
04
Disease associations
Ventilator-associated pneumoniaCystic fibrosisNon-CF bronchiectasisChronic obstructive pulmonary disease (COPD)KeratitisBurn wound infections
05
Safety considerations
Potential for off-target effects on other metalloproteasesDevelopment of resistance to inhibitors
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