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Target intelligence / Profile preview
Electron Transport Chain (Mitochondrial) (ETC)
- Target
- ETC
- Molecular classification
- Enzyme Complex, Multi-subunit protein complex
01
Overview
The mitochondrial electron transport chain (ETC) is a series of protein complexes and small molecules embedded in the inner mitochondrial membrane. Its primary function is to transfer electrons from electron donors such as NADH and FADH₂ to molecular oxygen, which acts as the final electron acceptor. This process generates a proton gradient across the inner mitochondrial membrane, which drives ATP synthesis via chemiosmosis—a process known as oxidative phosphorylation.
- Other names
- Mitochondrial Respiratory ChainOxidative Phosphorylation System
02
Mechanism of action
Inhibition of electron transport, uncoupling of oxidative phosphorylation
03
Biological functions
Energy productionATP synthesisElectron transportProton gradient generationRedox regulationReactive oxygen species generationRegulation of apoptosisCell signaling
04
Disease associations
Mitochondrial disordersNeurodegenerative diseasesCardiomyopathyCancerMetabolic disordersAging
05
Safety considerations
Production of reactive oxygen speciesImpaired cellular respirationMetabolic imbalances
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