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Embryonic stem cell related (non-protein coding) (ESRG)

Target: ESRG
Molecular classification: Other (long non-coding RNA, lncRNA)

Overview

Embryonic stem cell related (non-protein coding) (ESRG) is a long non-coding RNA gene mainly expressed in human embryonic stem cells[5][3][7]. It is associated with stem cell pluripotency and maintenance, and high ESRG expression is a marker of undifferentiated human embryonic stem cells[1][5]. The gene is primarily localized to the cell nucleus and does not code for a functional protein product[5][3][7]. ESRG has been studied in the context of embryonic stem cell biology and may be dysregulated in some cancers, such as colorectal cancer and germinoma, but there is currently no evidence that it is a classical therapeutic target like a receptor or enzyme[5]. It is classified as a non-coding RNA, specifically a long non-coding RNA (lncRNA), and is not known to interact with any drugs or serve as a clinical biomarker at present[5].

Other names: HESRGhuman embryonic stem cell related geneembryonic stem cell-related gene proteinhES cell-related gene protein

Biological functions

Regulatory RNAPotential involvement in pluripotency and stem cell maintenance

Disease associations

Cancer (e.g., colorectal cancer, germinoma)Other (possible link to stem cell states)

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