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Enoyl-[acyl-carrier-protein] reductase I (FabI)

Target: FabI
Molecular classification: Enzyme

Overview

FabI is the primary enoyl-acyl carrier protein (ACP) reductase enzyme in the type II fatty acid synthesis (FAS II) pathway, essential for bacterial and plant fatty acid biosynthesis. It catalyzes the NADH- or NADPH-dependent reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to ACP, converting trans-2-enoyl-ACP substrates to acyl-ACP. FabI has been validated as an effective antibacterial drug target; inhibiting this enzyme leads to significant reductions in bacterial viability both extracellularly and intracellularly.

Mechanism of action

Inhibition of fatty acid synthesis

Biological functions

Fatty acid biosynthesisReduction of enoyl-ACP

Disease associations

Infection

Safety considerations

Potential for off-target effects if inhibitors are not selective for bacterial FabI over eukaryotic homologs.

Interacting drugs

AFN-1252

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