Enoyl-CoA delta isomerase 1, mitochondrial (ECI1)

Enoyl-CoA delta isomerase 1, mitochondrial (ECI1) is a mitochondrial enzyme crucial for the beta-oxidation of unsaturated fatty acids. It catalyzes the isomerization of both 3-cis and 3-trans double bonds in enoyl-CoA intermediates to the 2-trans form, a necessary step for the continued metabolism of unsaturated fatty acids. ECI1 is considered an auxiliary enzyme but is essential for efficient fatty acid catabolism, enabling organisms to derive energy from a variety of lipid species. Its activity is particularly important in tissues with high energetic demand, such as muscle. ECI1 belongs to the hydratase/isomerase superfamily and is encoded by the ECI1 gene on chromosome 16. Dysregulation or altered expression of ECI1 has been implicated in the progression and aggressiveness of certain cancers, and it may have utility as a prognostic biomarker[1][2][3][4][5][6][8].

Other names

3,2-trans-enoyl-CoA isomerase, mitochondrialDodecenoyl-CoA delta isomeraseΔ3(cis),Δ2(trans)-enoyl-CoA isomeraseAcetylene-allene isomeraseDCI

Isomerization of carbon-carbon double bonds in acyl-CoA intermediates to enable continued beta-oxidation