Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Enteric nervous system nerve ending (colonic)
- Molecular classification
- Other (anatomical structure; comprises various neuron types such as motor, sensory, secretomotor neurons, not a single molecular entity)
01
Overview
Enteric nerve endings in the colon are the terminal regions of neurons belonging to the enteric nervous system, a complex network controlling local and reflexive gut functions such as motility, secretion, absorption, blood flow, and coordination with the immune system. These nerve endings release various neurotransmitters (acetylcholine, nitric oxide, vasoactive intestinal peptide, substance P, etc.), integrate signals from both intrinsic ENS circuits and extrinsic autonomic fibers, and are critical for the normal physiological regulation of the colon. These structures are not single molecular targets, but rather anatomical endpoints of diverse neuronal populations
- Other names
- colonic enteric neuronscolonic ENS terminalsnerve endings in colon ENS
02
Mechanism of action
Modulation of neurotransmitter release (acetylcholine, NO, substance P, etc.) Inhibition/stimulation of smooth muscle contraction Alteration of secretory/absorptive activity
03
Biological functions
Regulation of gut motilityRegulation of secretionLocal blood flow controlNeuroimmune communicationSensation (visceral)
04
Disease associations
Gastrointestinal dysmotilityIrritable bowel syndromeInflammatory bowel diseaseVisceral pain
05
Safety considerations
Non-specific action risks: targeting nerve endings risks broad effects such as constipation, ileus, impaired secretion, or off-target neurological effectsENS-wide effects may induce dysmotility or worsen disease state
06
Interacting drugs
Opioids (e.g., morphine — inhibits motility via enteric pathways)
4 more in the full profile.
Beyond the preview
Go deeper on Enteric nervous system nerve ending (colonic).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Enteric nervous system nerve ending (colonic).