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Target intelligence / Profile preview
Epidermal Growth Factor Receptor (Truncated) (EGFRt)
- Target
- EGFRt
- Molecular classification
- Receptor Tyrosine Kinase, Receptor, ErbB/HER family
01
Overview
The epidermal growth factor receptor (EGFR) is a transmembrane protein and member of the ErbB family of receptor tyrosine kinases. The truncated form (EGFRt) typically refers to engineered or naturally occurring versions of EGFR that lack part of the extracellular domain or other regions. EGFRt is often constitutively active, promoting cell proliferation and survival, and is associated with various cancers. Therapeutic targeting of EGFRt includes tyrosine kinase inhibitors, monoclonal antibodies, and immunotherapeutics, but resistance mechanisms frequently emerge.
- Other names
- EGFR truncatedTruncated EGFRHER1 truncatedErbB1 truncatedEGFRvIII
02
Mechanism of action
Tyrosine kinase inhibition; antibody-mediated receptor blockade; immunotherapeutic targeting
03
Biological functions
Cell proliferationCell survivalCell differentiationCell migrationSignal transductionTyrosine kinase activity
04
Disease associations
CancerNon-small-cell lung cancerGlioblastomaColorectal cancerHead and neck cancers
05
Safety considerations
Resistance to targeted therapiesOff-target effects of tyrosine kinase inhibitorsImmune-related adverse events with immunotherapies
06
Interacting drugs
Erlotinib
1 more in the full profile.
07
Biomarkers
EGFR expression levelsEGFR mutationsEGFR truncations (e.g., EGFRvIII)
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